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Oxycodone 20 mg has no antagonistic qualities and is a complete opioid agonist. In the brain and spinal cord, it binds to kappa, mu, and delta opiate receptors. The main therapeutic effects are sedative, analgesic, and anxiolytic. The sphincter of Oddi may spasm as a result of opioids. This depends on whether you are taking standard oxycodone capsules, tablets, or liquid, or slow-release tablets. Standard 20mg of oxy takes 30 to 60 minutes to work, but this wears off after 4 to 6 hours